Acute Rheumatic Fever (PPT) – Dr. Akif Ahamad Baig

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Acute Rheumatic Fever (ARF) is an inflammatory disease that can develop after a group A streptococcal throat infection (Streptococcus pyogenes). It primarily affects children and young adults and can involve the heart, joints, skin, and brain. The most serious complication is rheumatic heart disease, where the heart valves become damaged. ARF is diagnosed based on clinical criteria (Jones criteria), which include evidence of a preceding strep infection, along with major symptoms like arthritis, carditis, and chorea, and minor symptoms such as fever and elevated inflammatory markers. Treatment focuses on eradicating the infection, reducing inflammation, and preventing recurrences.

Description

— Acute rheumatic fever

An acute illness caused by an autoimmune response to infection with group A Streptococcus, leading to a range of possible symptoms and signs affecting any or all of heart, joints, brain, skin and subcutaneous tissues

—Rheumatic carditis

Active inflammation of the heart tissues, most importantly the mitral and/or the aortic valves, caused by acute rheumatic fever. Rheumatic carditis can lead to chronic damage that remains after the acute inflammatory episode has resolved

 

—Rheumatic heart disease

The persistent damage to heart valves resulting in mitral and/or aortic regurgitation, or in long-standing cases stenosis, that remains as a result of acute rheumatic fever with rheumatic carditis. Complications of rheumatic heart disease include heart failure, embolic stroke, endocarditis and atrial fibrillation.

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