Drug of Choice
- Absence Seizures – Ethosuximide
- Acute Coronary Syndrome (ACS) – Aspirin
- Acute Gastroenteritis – Oral Rehydration Solution (ORS)
- Acute Intermittent Porphyria – Hemin
- Acute Ischemic Stroke – Alteplase (tPA)
- Acute Mesenteric Ischemia – Surgical Intervention (No specific drug)
- Acute Myocardial Infarction (STEMI) – Aspirin + Thrombolytic (Alteplase)
- Acute Pancreatitis – Supportive Care (IV fluids, analgesics)
- Acute Pyelonephritis – Ciprofloxacin
- Acute Spinal Cord Injury – Methylprednisolone
- Acute Variceal Bleeding – Octreotide
- Addison’s Disease – Hydrocortisone
- Adrenal Crisis – Hydrocortisone (IV)
- Alzheimer’s Disease – Donepezil
- Anaphylaxis – Epinephrine (IM)
- Amyotrophic Lateral Sclerosis (ALS) – Riluzole
- Angioedema (Hereditary) – C1 Esterase Inhibitor (IV)
- Antiphospholipid Syndrome (APS) – Warfarin
- Asthma (Acute Exacerbation) – Salbutamol (Inhaled)
- Asthma (Chronic Management) – Inhaled Corticosteroids (e.g., Budesonide)
- Atrial Fibrillation (Rate Control) – Metoprolol
- Atrial Fibrillation (Rhythm Control) – Amiodarone
- Autism Spectrum Disorder – No specific pharmacological treatment
- Bell’s Palsy – Prednisolone
- Bradycardia – Atropine
- Bacterial Endocarditis (Native Valve) – Ceftriaxone + Vancomycin
- Bacterial Endocarditis (Prosthetic Valve) – Vancomycin + Gentamicin + Rifampicin
- Bacterial Meningitis (Adult) – Ceftriaxone + Vancomycin
- Bacterial Meningitis (Neonates) – Ampicillin + Gentamicin
- Bell’s Palsy – Prednisolone
- Bradycardia (Symptomatic) – Atropine
- Cardiogenic Shock – Dobutamine
- Chronic Bronchitis – Inhaled Corticosteroids
- Chronic Heart Failure – ACE Inhibitors
- Chronic Kidney Disease (CKD) – ACE Inhibitors/ARBs
- Chronic Mesenteric Ischemia – Surgical Revascularization
- Cluster Headache (Acute) – 100% Oxygen
- Cluster Headache (Prophylaxis) – Verapamil
- COPD (Chronic Obstructive Pulmonary Disease) – Tiotropium (Long-acting anticholinergic)
- COVID-19 (Severe) – Dexamethasone
- Crohn’s Disease (Mild to Moderate) – Mesalamine
- Crohn’s Disease (Severe) – Infliximab
- Cryptococcal Meningitis – Amphotericin B + Flucytosine
- Diabetes Mellitus Type 1 – Insulin
- Diabetes Mellitus Type 2 – Metformin
- Diabetic Ketoacidosis – Insulin (IV)
- Dilated Cardiomyopathy – ACE Inhibitors
- Duchenne Muscular Dystrophy – Prednisone
- Eclampsia – Magnesium Sulfate
- Eisenmenger Syndrome – Sildenafil
- Encephalitis (Herpes Simplex Virus) – Acyclovir
- Endometrial Cancer – Paclitaxel + Carboplatin
- Essential Tremor – Propranolol
- Focal Seizures – Carbamazepine
- GERD (Gastroesophageal Reflux Disease) – Proton Pump Inhibitors (e.g., Omeprazole)
- Guillain-Barré Syndrome – Intravenous Immunoglobulin
- Hashimoto’s Thyroiditis (Hypothyroidism) – Levothyroxine
- Hepatitis B (Chronic) – Tenofovir
- Hepatitis C (Chronic, Genotype 1) – Sofosbuvir + Ledipasvir
- Hypertension – ACE Inhibitors (e.g., Enalapril)
- Hypertensive Emergency – Sodium Nitroprusside
- Idiopathic Intracranial Hypertension – Acetazolamide
- Lambert-Eaton Myasthenic Syndrome – 3,4-Diaminopyridine
- Lennox-Gastaut Syndrome – Clobazam
- Lambert-Eaton Myasthenic Syndrome – 3,4-Diaminopyridine
- Lyme Disease – Doxycycline
- Malaria (Plasmodium falciparum, Uncomplicated) – Artemether-Lumefantrine
- Malaria (Severe) – Artesunate (IV)
- Malignant Hypertension – Sodium Nitroprusside
- Marfan Syndrome (Cardiac Manifestations) – Beta Blockers
- Meningitis (Bacterial) – Ceftriaxone + Vancomycin
- Methicillin-Resistant Staphylococcus aureus (MRSA) – Vancomycin
- Migraine (Acute Attack) – Sumatriptan
- Migraine (Prophylaxis) – Propranolol
- Mitral Regurgitation – Diuretics
- Mitral Stenosis – Diuretics
- Multiple Endocrine Neoplasia Type 1 (MEN 1) – Surgical Resection of Tumors
- Multiple Endocrine Neoplasia Type 2 (MEN 2) – Surgical Resection
- Multiple Sclerosis (Acute Exacerbation) – Methylprednisolone
- Myasthenia Gravis – Pyridostigmine
- Myoclonic Seizures – Valproate
- Narcolepsy (Excessive Daytime Sleepiness) – Modafinil
- Neisseria gonorrhoeae Infection – Ceftriaxone
- Neurosyphilis – Penicillin G
- Osteoarthritis – NSAIDs (e.g., Ibuprofen)
- Osteoporosis – Bisphosphonates
- Paget’s Disease of Bone – Zoledronic Acid
- Parkinson’s Disease – Levodopa + Carbidopa
- Patent Ductus Arteriosus (PDA) in Preterm Infants – Indomethacin
- Peptic Ulcer Disease (H. pylori-related) – Clarithromycin + Amoxicillin + PPI
- Peripheral Artery Disease – Aspirin
- Pericarditis – NSAIDs (e.g., Ibuprofen)
- Pheochromocytoma – Phenoxybenzamine
- Pneumonia (Community-Acquired) – Amoxicillin
- Pneumonia (Hospital-Acquired) – Piperacillin-Tazobactam
- Pneumocystis jiroveci Pneumonia (PCP) – Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Polycystic Ovary Syndrome (PCOS) – Oral Contraceptive Pills
- Portal Hypertension – Propranolol
- Postherpetic Neuralgia – Gabapentin
- Primary Biliary Cholangitis – Ursodeoxycholic Acid
- Primary Hyperparathyroidism – Parathyroidectomy
- Primary Sclerosing Cholangitis – Ursodeoxycholic Acid
- Progressive Multifocal Leukoencephalopathy – Antiretroviral Therapy
- Pulmonary Embolism – Heparin
- Pulmonary Fibrosis (Idiopathic) – Pirfenidone
- Pulmonary Hypertension – Sildenafil
- Rabies (Post-Exposure Prophylaxis) – Rabies Immunoglobulin + Vaccine
- Rheumatic Fever (Prophylaxis) – Penicillin
- Sarcoidosis (Pulmonary Involvement) – Prednisolone
- Schistosomiasis – Praziquantel
- Seizures (Febrile) Prophylaxis – Diazepam
- Spinal Muscular Atrophy – Nusinersen
- Status Epilepticus – Lorazepam (IV)
- Subarachnoid Hemorrhage (Vasospasm) – Nimodipine
- Systemic Lupus Erythematosus (SLE) – Hydroxychloroquine
- Temporal Arteritis (Giant Cell Arteritis) – Prednisolone
- Tetanus – Metronidazole
- Thyroid Storm – Propranolol
- Torsades de Pointes – Magnesium Sulfate
- Trigeminal Neuralgia – Carbamazepine
- Tuberculosis (Pulmonary) – Isoniazid + Rifampicin + Pyrazinamide + Ethambutol
- Toxoplasmosis (CNS Infection) – Pyrimethamine + Sulfadiazine
- Trichomoniasis – Metronidazole
- Tuberculosis (Latent) – Isoniazid
- Tuberculosis (Miliary) – Isoniazid + Rifampicin + Pyrazinamide + Ethambutol
- Tuberculous Meningitis – Isoniazid + Rifampicin + Pyrazinamide + Ethambutol + Steroids
- Turner Syndrome (Short Stature) – Growth Hormone
- Typhoid Fever – Ceftriaxone
- Urinary Tract Infection (Uncomplicated) – Nitrofurantoin
- Vasovagal Syncope – Fludrocortisone
- Ventricular Fibrillation – Amiodarone
- Ventricular Septal Defect (Large) – Surgical Repair
- Ventricular Tachycardia – Amiodarone
- Wegener’s Granulomatosis (Granulomatosis with Polyangiitis) – Cyclophosphamide + Corticosteroids
- Wernicke’s Encephalopathy – Thiamine (IV)
- Wilson’s Disease (Neurological Symptoms) – Penicillamine