GENERAL MEDICINE – Add On’s (Free View)

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Topic	Key Details	Document Reference
Sepsis	Life-threatening organ dysfunction caused by a dysregulated host response to infection. High mortality rate.	Sepsis.pdf
ARDS (Acute Respiratory Distress Syndrome)	Severe respiratory condition with dyspnea, hypoxemia, and diffuse lung damage. Non-cardiogenic pulmonary edema.	ARDS.pdf
Behçet Syndrome	Chronic systemic vasculitis presenting with recurrent oral/genital ulcers, skin lesions, and ocular complications.	Behcet Syndrome.pdf
Clinical Trials in Diabetes	Covers key trials like DCCT, UKPDS, and Diabetes Prevention Program, focusing on glycemic control and treatment outcomes.	Clinical Trials.pdf

Sepsis:
- Defined by SOFA score changes, indicating organ dysfunction due to infection.
- Management includes antibiotics, fluid resuscitation, and vasopressors.
ARDS:
- Diagnosed by acute onset, bilateral opacities on X-ray, and hypoxemia (PaO₂/FiO₂ ≤300).
- Management includes ventilation strategies like low tidal volume and prone positioning.
Behçet Syndrome:
- Features recurrent mucocutaneous ulcers, eye inflammation, and systemic involvement (joints, vessels, CNS).
- Treatment involves steroids and immunosuppressive agents.
Clinical Trials in Diabetes:
- Trials emphasize intensive glycemic control, lifestyle modifications, and drug efficacy (e.g., metformin, ACEIs).
- Findings highlight prevention of complications and treatment personalization.

1., Sepsis:
Understanding the pathophysiology, diagnosis, and management of sepsis and septic shock.
Insights into the use of SOFA scores and quick SOFA (qSOFA) for assessing organ dysfunction.
Evidence-based strategies for fluid resuscitation, antimicrobial therapy, and vasopressor use.
ARDS (Acute Respiratory Distress Syndrome):
Diagnostic criteria, including imaging and oxygenation parameters.
Phases of ARDS and their clinical implications.
Management strategies like low tidal volume ventilation, prone positioning, and fluid balance.
Behçet Syndrome:
Recognition of systemic symptoms like oral/genital ulcers, eye lesions, and vasculitis.
Diagnostic criteria and the importance of the Pathergy test.
Treatment options, including topical steroids, systemic immunosuppressants, and their targeted use.
Clinical Trials in Diabetes:
Key clinical trial findings (e.g., DCCT, UKPDS) and their impact on glycemic control strategies.
Effectiveness of lifestyle interventions and medications like metformin, ACE inhibitors, and SGLT-2 inhibitors.
Understanding trial outcomes to guide individualized patient care.
Critical Thinking in Medicine:
Integrating trial data and clinical evidence into practice.
Balancing patient safety, efficacy, and cost-effectiveness in treatment plans.
Developing a structured approach to diagnosing and managing complex conditions.

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